Key result
Bilateral renal denervation prevented the elevation of systolic blood pressure induced by chronic cold exposure in rats (116 mmHg vs 139 mmHg in sham-operated controls at 5 weeks).
Why the study?
Does bilateral renal denervation prevent the elevation of blood pressure and cardiac hypertrophy induced by chronic exposure to cold in male rats?
Population
36 male rats (4 groups of 9)
Comparison
Bilateral renal denervation followed by chronic… vs Sham operation with cold exposure, RD at 25…
Design
Preclinical
Follow-up
7 weeks
Authors
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Animal data suggest renal denervation prevents cold-induced hypertension; leaves open applicability to clinical practice.
Does bilateral renal denervation prevent the elevation of blood pressure and cardiac hypertrophy induced by chronic exposure to cold in male rats?
Absolute Event Rate: 116% vs 139%
In a rat model, bilateral renal denervation prevented cold-induced hypertension but did not prevent cardiac hypertrophy.
Sun et al. (1995) studied Cold-induced elevation of blood pressure and cardiac hypertrophy (n=36). Bilateral renal denervation vs. Sham operation was evaluated on Systolic blood pressure at 5 weeks of cold exposure. Bilateral renal denervation prevented the elevation of systolic blood pressure induced by chronic cold exposure in rats (116 mmHg vs 139 mmHg in sham-operated controls at 5 weeks).
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