July 1, 1991Journal of Applied Physiology

Role of the sympathetic nervous system in cold-induced hypertension in rats

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Population

20 male rats prepared with indwelling catheters in the femoral artery and vein

Comparison

Chronic exposure to cold (6 +/- 2 degrees C) vs Kept at room temperature (26 +/- 2 degrees C)

Design

Preclinical

Follow-up

at least 19 days

Authors

PPPaula E. PapanekMarquette University CWCharles E. WoodAmerican Association of Colleges of Pharmacy MFMelvin J. FreglyAmerican Association of Colleges of Pharmacy

Discussion

Member takes

Implication

Does not yet inform human hypertension management; extends animal evidence linking cold to sympathetic and baroreflex changes.

Structured PICO

Population

20 male rats prepared with indwelling catheters in the femoral artery and vein

Intervention

Chronic exposure to cold (6 +/- 2 degrees C)

Comparator

Kept at room temperature (26 +/- 2 degrees C)

Outcome

Systolic, diastolic, and mean blood pressures, baroreflex sensitivity, and plasma norepinephrine and epinephrine concentrationssurrogate

Chronic cold exposure in rats induces hypertension associated with sustained sympathetic nervous system activation and decreased baroreflex sensitivity.

Cite This Study

Papanek et al. (1991) studied this question.

synapsesocial.com/papers/6a80b9f81024bacc9692cb7e https://doi.org/10.1152/jappl.1991.71.1.300

Topics

Hypertension management

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