Key result
Cold exposure markedly increased urinary catecholamine concentrations in all strains, with significantly enhanced epinephrine responses in stroke-prone and stroke-resistant spontaneously hypertensive rats.
Population
Male stroke-prone spontaneously hypertensive rats, stroke-resistant spontaneously hypertensive rats, and…
Comparison
Cold exposure (4 degrees C) for 4 hours vs Room temperature
Design
Preclinical
Follow-up
4 hours
Authors
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May implicate enhanced catecholamine responses in experimental hypertension; leaves open relevance to human disease.
Prehypertensive and hypertensive spontaneously hypertensive rats exhibit enhanced sympathetic and neurally-mediated adrenal medullary responses to cold exposure, suggesting a role for altered catecholamine secretion in experimental hypertension.
Yamori et al. (1985) studied Hypertension. Cold exposure vs. Room temperature was evaluated on Urinary catecholamine excretion. Cold exposure markedly increased urinary catecholamine concentrations in all strains, with significantly enhanced epinephrine responses in stroke-prone and stroke-resistant spontaneously hypertensive rats.
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