January 1, 1999American Journal of HypertensionOpen Access

Cold acclimation-induced increase of systolic blood pressure in rats is associated with volume expansion

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Why the study?

Does cold acclimation increase systolic blood pressure and plasma volume in 6-month-old male Wistar rats?

Population

6-month-old male Wistar rats

Comparison

Cold acclimation followed by reacclimation to 26… vs Thermoneutrality (26 degrees C for 7 weeks)

Design

Preclinical

Follow-up

21 weeks total

Authors

NRNatalia I. Roukoyatkina

Discussion

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Implication

Animal data link cold acclimation to volume-driven hypertension; leaves open relevance to human blood pressure regulation.

Structured PICO

Does cold acclimation increase systolic blood pressure and plasma volume in 6-month-old male Wistar rats?

Population

6-month-old male Wistar rats

Intervention

Cold acclimation (6 degrees C for 9 weeks) followed by reacclimation to 26 degrees C for 5 weeks

Comparator

Thermoneutrality (26 degrees C for 7 weeks)

Outcome

Systolic blood pressure, average daily water consumption, circulating plasma volume, and whole blood viscositysurrogate

Cold acclimation in rats induces a volume-associated hypertension that is sustained even after rewarming and normalization of volume expansion.

Cite This Study

Natalia I. Roukoyatkina (1999) studied this question.

synapsesocial.com/papers/6a1cb1bd566b67b7d585cb4a https://doi.org/10.1016/s0895-7061(98)00213-1

Topics

Hypertension management

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Cold acclimation-induced increase of systolic blood pressure in rats is associated with volume expansion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Cold acclimation-induced increase of systolic blood pressure in rats is associated with volume expansion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider