Key result
Four days of cold exposure in rats progressively increased renal sympathetic nerve activity and shifted its baroreflex curve, with effects persisting after exposure ended.
Why the study?
Direct measurement of sympathetic nerve activity during cold-induced hypertension and changes in baroreflex control of sympathetic nerve activity remained unexplored.
Does cold exposure increase renal sympathetic nerve activity and alter baroreflex control in rats?
Population
Chronically instrumented rats
Comparison
Cold exposure (10 °C) over 4 days vs control period (24 °C)
Design
Animal experimental study
Follow-up
4 days
Authors
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Hypothesis-generating for sympathetic pathways in cold-induced hypertension; does not support clinical practice changes.
Does cold exposure increase renal sympathetic nerve activity and alter baroreflex control in rats?
Four days of cold exposure in rats causes a progressive and persistent increase in renal sympathetic nerve activity, suggesting a self-activating pathway for cold-induced hypertension.
Yoshimoto et al. (2025) studied Cold-induced hypertension. Cold exposure (10 °C) vs. Control period (24 °C) was evaluated on Renal and lumbar sympathetic nerve activities, heart rate, and arterial pressure. Four days of cold exposure in rats progressively increased renal sympathetic nerve activity and shifted its baroreflex curve, with effects persisting after exposure ended.
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