Why the study?
Does surgical renal denervation reduce mean arterial pressure in Yucatan miniature swine with established DOCA hypertension?
Population
4 Yucatan miniature swine (YMS) with established DOCA hypertension
Comparison
Surgical renal denervation (RDX) vs Pre-RDX baseline
Design
Preclinical
Follow-up
3 weeks
Authors
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Supports renal nerve role in swine DOCA hypertension maintenance; hypothesis-generating for human renal denervation efficacy.
Does surgical renal denervation reduce mean arterial pressure in Yucatan miniature swine with established DOCA hypertension?
Surgical renal denervation significantly reduces mean arterial pressure in a swine model of established DOCA hypertension, suggesting a role for renal nerves in the maintenance of hypertension.
O’Hagan et al. (1990) studied this question.
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