Why the study?
Does hexamethonium bromide normalize mean arterial pressure in DOCA-hypertensive Yucatan miniature swine?
Population
Chronically instrumented conscious 2-kidney DOCA treated Yucatan miniature swine and normal controls
Comparison
Hexamethonium bromide (HMB) vs Normal control animals
Design
Preclinical
Authors
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Supports neurogenic hypertension in DOCA-swine model; leaves open clinical translation of sympathetic blockade to human essential hypertension.
Does hexamethonium bromide normalize mean arterial pressure in DOCA-hypertensive Yucatan miniature swine?
In a swine model, DOCA administration produces a neurogenic form of hypertension driven by increased peripheral sympathetic nerve activity, analogous to human essential hypertension.
Zambraski et al. (1986) studied this question.
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