Why the study?
Obesity is thought to accelerate normal ageing and has been linked to neurodegenerative processes, possibly manifesting as accelerated brain ageing.
Does obesity accelerate brain ageing (increase brain age delta) compared to normal-weighted individuals?
Population
Adults aged 18–90 years from the Cam-CAN dataset
Comparison
Obese participants vs matched normal-weighted individuals
Design
Cross-sectional study
Key result
Obesity was associated with a greater brain age delta for grey matter and functional connectivity compared to normal-weight individuals, with the earliest effect evident in the 40-60 age range.
Authors
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Obesity-linked brain ageing differences in mid-life warrant no practice change yet; leaves open causality and intervention effects.
Cross-Sectional
Does obesity accelerate brain ageing (increase brain age delta) compared to normal-weighted individuals?
Obesity is associated with accelerated brain ageing as measured by neuroimaging, suggesting that early intervention on obesity may help maintain brain health and reduce late-life neurodegenerative risks.
Vanni et al. (2025) conducted a cross-sectional in Obesity. Obesity vs. Normal-weighted individuals was evaluated on Brain age delta (discrepancy between brain-based predicted age and chronological age). Obesity was associated with a greater brain age delta for grey matter and functional connectivity compared to normal-weight individuals, with the earliest effect evident in the 40-60 age range.
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