Key result
Disruption of metabolic transduction pathways between the cytosol and mitochondrial matrix compromises energetic support and is implicated in the pathogenesis of heart failure.
Design
Review
Authors
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Metabolic cytosol-mitochondrial links merit targeted HF investigation; leaves open whether modulating energetic efficiency improves outcomes.
The review highlights the critical role of metabolic transduction pathways between the cytosol and mitochondria in the pathogenesis of heart failure.
Carley et al. (2014) conducted a review in Heart failure. Disruption of metabolic transduction pathways between the cytosol and mitochondrial matrix compromises energetic support and is implicated in the pathogenesis of heart failure.
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