Key result
The second window of preconditioning normalized oxidative metabolism of long-chain free fatty acids and protected regional contractile function during subsequent ischaemia in pigs.
Why the study?
Does the second window of preconditioning normalize LCFA oxidation and improve contractile function during low-flow ischaemia in a porcine model?
Does the second window of preconditioning normalize LCFA oxidation and improve contractile function during low-flow ischaemia in a porcine model?
The second window of preconditioning normalizes oxidative metabolism of long-chain free fatty acids and improves regional contractile function during subsequent low-flow ischaemia in a porcine model.
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May inform mechanistic studies of late preconditioning; leaves open translation to human low-flow ischemia.
Kudej et al. (2011) studied Ischaemia (n=17). Second window of preconditioning (SWOP) vs. Coronary artery stenosis without preconditioning was evaluated on Long-chain free fatty acid (LCFA) oxidation and contractile function. The second window of preconditioning normalized oxidative metabolism of long-chain free fatty acids and protected regional contractile function during subsequent ischaemia in pigs.
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