High-gain and broadband in vivo amplifiers enabled by matched materials

Y J Zheng; Qi Li; Xinyue Wang; Chengwen Wu; Jupeng Chen; Zhibo Ren; Yiheng Chen; Xiran Pan; Xun Lei; Wenlong Li; Zhiyuan Xiong; Gaoyang Ge; Wenxi Sun; Peiyun Li; Suqing Gao; Biqin Yang; Siqi Fang; Jingcao Xu; Jiatong Li; Xiaochuan Dai; Ting Lei; Zhi Zhang

doi:10.1038/s41467-026-75627-z

Key Points

The aim is to develop high-gain, broadband in vivo amplifiers using matched materials for improved signal quality.
In vivo amplification of mouse electrocorticographic (ECoG) signals.
Evaluation of biocompatibility and signal quality.
Material-device-circuit framework established for OECT-based amplifiers.
Achieved bandwidth above 600 Hz at 0.6 V.
Demonstrated ultralow power consumption of 0.57 nW at 0.2 V.
Confirmed good biocompatibility and superior signal quality in ECoG amplification.

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Abstract

, a bandwidth above 600 Hz at 0.6 V, and an ultralow power consumption down to 0.57 nW at 0.2 V. We further demonstrate in vivo amplification of mouse electrocorticographic (ECoG) signal with good biocompatibility and superior signal quality. This work establishes a general material-device-circuit framework and design guidelines for OECT-based amplifiers.

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Zheng et al. (2026) studied this question.

synapsesocial.com/papers/6a5c68af118b92953e3ed4a7 https://doi.org/10.1038/s41467-026-75627-z

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High-gain and broadband in vivo amplifiers enabled by matched materials

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High-gain and broadband in vivo amplifiers enabled by matched materials

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