Venepuncture versus heel lance for blood sampling in term neonates

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Key Points

This systematic review compares venepuncture and heel lance in term neonates, focusing on pain response during blood sampling.
Conducted a systematic review of RCTs and quasi-RCTs comparing venepuncture and heel lance.
Included 8 studies with 826 neonates from various income countries.
Performed meta-analysis calculating standardized mean differences and risk ratios.
Venepuncture probably reduces pain compared to heel lance (SMD -1.34, 95% CI -1.55 to -1.14).
Venepuncture likely decreases the need for multiple skin punctures (RR 0.63, 95% CI 0.40 to 0.97).
Evidence is uncertain about venepuncture's effect on skin punctures when sweet-tasting solutions are used (RR 7.00, 95% CI 0.38 to 129.93).

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Randomized trial compares pain response of venepuncture versus heel lance in neonates, suggesting venepuncture may be preferable.

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Martins et al. (2026) studied this question.

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