Key result
Extracorporeal life support, intravenous lipid emulsion, and CytoSorb successfully treated a young woman with severe takotsubo cardiomyopathy after an 18 g venlafaxine overdose.
Why the study?
Can the combination of intravenous lipid emulsion, extracorporeal life support, and CytoSorb successfully treat cardiogenic shock and Takotsubo cardiomyopathy secondary to massive venlafaxine intoxication?
Case Report (n=1)
Can the combination of intravenous lipid emulsion, extracorporeal life support, and CytoSorb successfully treat cardiogenic shock and Takotsubo cardiomyopathy secondary to massive venlafaxine intoxication?
Massive venlafaxine intoxication causing Takotsubo cardiomyopathy and cardiogenic shock can be successfully managed with a combination of extracorporeal life support, intravenous lipid emulsion, and CytoSorb.
May inform rescue strategies for refractory venlafaxine-induced shock; leaves open efficacy and generalizability pending prospective data.
We describe a young patient who ingested 18 g (240 times the daily therapeutic dose) of venlafaxine in a suicide attempt. She developed severe cardiomyopathy in a takotsubo distribution causing cardiogenic shock and multi-organ dysfunction syndrome (MODS). She was successfully treated with intravenous lipid emulsion (ILE), extracorporeal life support (ECLS) and CytoSorb®. This is remarkable as, to the best of the authors' knowledge, this is the highest amount of venlafaxine intake seen in the literature with a nonfatal outcome.
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Schroeder et al. (2017) conducted a case report in Venlafaxine Intoxication with Takotsubo Cardiomyopathy (n=1). Extracorporeal life support, intravenous lipid emulsion, and CytoSorb was evaluated on Clinical outcome. Extracorporeal life support, intravenous lipid emulsion, and CytoSorb successfully treated a young woman with severe takotsubo cardiomyopathy after an 18 g venlafaxine overdose.
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