Key result
Early implantation of an extracorporeal life support (ECLS) system successfully managed refractory cardiovascular shock in a patient with severe venlafaxine intoxication, resulting in full recovery.
Why the study?
Very few reports exist on serious cardiac complications associated with the intake of serotonin-noradrenaline reuptake inhibitors.
Does early implantation of an extracorporeal life support (ECLS) system improve outcomes in a patient with refractory cardiovascular shock due to severe venlafaxine intoxication?
Case Report (n=1)
No
Does early implantation of an extracorporeal life support (ECLS) system improve outcomes in a patient with refractory cardiovascular shock due to severe venlafaxine intoxication?
Early use of extracorporeal life support (ECLS) can be a successful bridging strategy for refractory cardiovascular shock secondary to severe venlafaxine intoxication.
May warrant ECLS consideration in refractory venlafaxine shock; hypothesis-generating case report requiring prospective validation.
Very few reports exist on serious cardiac complications associated with intake of serotonin-noradrenaline reuptake inhibitors. This paper describes and discusses the case of a patient who ingested a dose of 17.5 g venlafaxine. She developed a full serotonergic syndrome leading to multi-organ failure, including refractory cardiovascular shock, which was managed by early implantation of an extracorporeal life support (ECLS) system as a bridging strategy. This intervention was successful and resulted in full recovery of the patient.
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Marquetand et al. (2020) conducted a case report in Venlafaxine intoxication with refractory cardiogenic shock (n=1). Extracorporeal life support (ECLS) was evaluated on Patient survival and recovery. Early implantation of an extracorporeal life support (ECLS) system successfully managed refractory cardiovascular shock in a patient with severe venlafaxine intoxication, resulting in full recovery.
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