Key result
Intravenous lipid emulsion successfully treated refractory pulseless electrical activity cardiac arrest secondary to a massive venlafaxine overdose.
Why the study?
Does intravenous lipid emulsion improve survival in patients with refractory pulseless electrical activity cardiac arrest secondary to massive venlafaxine overdose?
Case Report (n=1)
Does intravenous lipid emulsion improve survival in patients with refractory pulseless electrical activity cardiac arrest secondary to massive venlafaxine overdose?
Intravenous lipid emulsion may serve as a life-saving rescue therapy for refractory cardiac arrest secondary to massive venlafaxine overdose when standard resuscitative measures fail.
May support lipid emulsion rescue in refractory venlafaxine-induced PEA arrest; hypothesis-generating and requires prospective trials.
Venlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant, has been associated with severe cardiotoxicity in massive overdoses. Treatment is usually supportive. Over the past decade, intravenous lipid emulsion has been gaining interest in the treatment of intoxications with lipophilic substances. We report a case of refractory pulseless electrical activity cardiac arrest following a massive overdose of venlafaxine successfully treated with intravenous lipid emulsion infusion.
No takes yet. Share an insight, caveat, or question.
John et al. (2018) conducted a case report in Severe venlafaxine intoxication with refractory pulseless electrical activity cardiac arrest (n=1). Intravenous lipid emulsion was evaluated on Cessation of pulseless electrical activity cardiac arrest. Intravenous lipid emulsion successfully treated refractory pulseless electrical activity cardiac arrest secondary to a massive venlafaxine overdose.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: