Key result
Pulse pressure variation accurately predicts fluid responsiveness with a sensitivity of 88% and specificity of 89%, provided its physiological limitations are respected.
Why the study?
Does pulse pressure variation accurately predict fluid responsiveness?
Does pulse pressure variation accurately predict fluid responsiveness?
Effect estimate: sensitivity 88%, specificity 89%
Pulse pressure variation is an accurate predictor of fluid responsiveness when its physiological limitations are understood and respected.
Since its first description in 1999 [1], many studies have demonstrated the value of pulse pressure variation (PPV) as a predictor of fluid responsiveness. These studies were pooled together in a recent meta-analysis [2] concluding that PPV predicts fluid responsiveness accurately (sensitivity 88%, specificity 89%), so long as limitations to its use [3,4] are understood and respected (Figure 1). Figure 1 Most common physiological limitations to the use of pulse pressure variation can be summarized as ‘LIMITS’. HR/RR, heart rate/respiratory rate.
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Michard et al. (2015) conducted an editorial in Fluid responsiveness. Pulse pressure variation (PPV) was evaluated on Fluid responsiveness (sensitivity 88%, specificity 89%). Pulse pressure variation accurately predicts fluid responsiveness with a sensitivity of 88% and specificity of 89%, provided its physiological limitations are respected.
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