Key result
In isolated coronary arteries from humans, cats, and rats, the order of potency for eliciting relaxation was verapamil > nitroglycerin > magnesium, with species differences in maximum relaxation.
Population
Isolated human, cat, and rat coronary arteries
Design
Preclinical
Authors
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Consistent potency order across species may guide model choice; leaves open translation to human coronary vasomotor therapy.
In isolated coronary arteries, verapamil is a more potent relaxant than nitroglycerin and magnesium across human, cat, and rat species, though species-specific differences exist in maximum relaxation capacity.
Sjögren et al. (1986) studied this question. Magnesium, nitroglycerin, and verapamil was evaluated on Vasomotor responses (relaxation). In isolated coronary arteries from humans, cats, and rats, the order of potency for eliciting relaxation was verapamil > nitroglycerin > magnesium, with species differences in maximum relaxation.
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