Key result
Magnesium at 1.0 mM significantly inhibited tonic contraction of isolated human coronary arteries compared with time-matched controls (48.7% vs 88.6%, P<0.01).
Population
Ring segments from isolated human coronary arteries obtained at autopsy within 5 hours after death…
Comparison
Magnesium at cumulative concentrations of… vs Time-matched controls, diltiazem (10-10 M), and…
Design
Preclinical
Authors
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Ex vivo magnesium relaxes isolated coronary arteries; leaves open translation to in vivo vasomotor tone or therapy.
Absolute Event Rate: 48.7% vs 88.6%
p-value: p=<0.01
In isolated human coronary arteries, magnesium inhibits both tonic and periodic contractions in a dose-dependent manner, differing from the specific effects of diltiazem and nitroglycerin.
Kimura et al. (1989) studied isolated human coronary arteries. Magnesium (Mg2+) vs. time-matched controls, diltiazem, and nitroglycerin was evaluated on tonic contraction (p=<0.01). Magnesium at 1.0 mM significantly inhibited tonic contraction of isolated human coronary arteries compared with time-matched controls (48.7% vs 88.6%, P<0.01).
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