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April 1, 1987Canadian Journal of Physiology and Pharmacology

Mg2+–Ca2+ interaction in contractility of vascular smooth muscle: Mg2+ versus organic calcium channel blockers on myogenic tone and agonist-induced responsiveness of blood vessels

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Why the study?

Does magnesium (Mg2+) compared to organic calcium channel blockers inhibit vascular tone in vascular smooth muscle?

Population

Microvascular and macrovascular smooth muscles (in vivo and in vitro models)

Comparison

Magnesium (Mg2+) vs Organic calcium channel blockers

Design

Review

Authors

BABurton M. AlturaAlbert Einstein College of MedicineBAB. T. AlturaState University of New YorkACAnthony CarellaSUNY Downstate Health Sciences University

Discussion

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Overview

Mg2+ may support non-selective vasodilation across vasculatures; leaves open comparative trials versus selective Ca2+ blockers.

Structured PICO

Does magnesium (Mg2+) compared to organic calcium channel blockers inhibit vascular tone in vascular smooth muscle?

P
Population
Microvascular and macrovascular smooth muscles (in vivo and in vitro models)
I
Intervention
Magnesium (Mg2+)
C
Comparator
Organic calcium channel blockers (verapamil, nimodipine, nitrendipine, nisoldipine)
O
Outcome
Myogenic, basal, and hormonal-induced vascular tone and contractilitysurrogate

Magnesium acts as a unique, non-selective calcium channel antagonist capable of inducing vasodilation across all regional vasculatures examined.

Cite This Study

Altura et al. (1987) studied this question.

synapsesocial.com/papers/6a82cb3ffdcaa17bff6d0ffbhttps://doi.org/10.1139/y87-120
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Intracellular Mg <sup>2+</sup> on the Properties of Large-Conductance, Ca <sup>2+</sup> -Dependent K <sup>+</sup> Channels in Rat Cerebrovascular Smooth Muscle Cells1995 · 19 citations
  2. 2Calcium channel antagonists modulate calcium by increasing magnesium influx: A hypothesis1988 · 3 citations
  3. 3Magnesium Inhibits Norepinephrine Release by Blocking N-Type Calcium Channels at Peripheral Sympathetic Nerve Endings2004 · 112 citations
  4. 4Modulation of the voltage-dependent K current by intracellular Mg in rat aortic smooth muscle cells2004 · 30 citations
  5. 5The role of Mg2+ in the inactivation of inwardly rectifying K+ channels in aortic endothelial cells.1995 · 30 citations