October 12, 2004HypertensionOpen Access

Magnesium Inhibits Norepinephrine Release by Blocking N-Type Calcium Channels at Peripheral Sympathetic Nerve Endings

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Population

Conscious spontaneously hypertensive rats, pithed Sprague-Dawley rats, perfused mesenteric arteries system…

Comparison

Magnesium (intravenous MgSO4 infusion 3x10… vs Normal Mg2+ solution or control conditions

Design

Preclinical

Authors

TSTatsuo ShimosawaInternational University of Health and Welfare KTKoji TakanoKansai Rosai Hospital KAKatsuyuki AndoSeiwa Hospital

Discussion

Member takes

Implication

Supports sympatholytic mechanism in preclinical models; hypothesis-generating for human hypertension trials.

Structured PICO

Population

Conscious spontaneously hypertensive rats (SHRs), pithed Sprague-Dawley rats, perfused mesenteric arteries system, and nerve growth factor-treated PC12 cells

Intervention

Magnesium (intravenous MgSO4 infusion 3x10(-6) mol/kg body weight/min or high Mg2+ concentration solution 4.8 mmol/L)

Comparator

Normal Mg2+ solution (1.2 mmol/L) or control conditions

Outcome

Blood pressure response, norepinephrine release, and voltage-gated Ca2+ currentssurrogate

Magnesium lowers blood pressure by inhibiting norepinephrine release via blockade of N-type calcium channels at sympathetic nerve endings, independent of its direct vasodilating action.

Cite This Study

Shimosawa et al. (2004) studied this question.

synapsesocial.com/papers/6a88f2b0c80974a9031a1e3e https://doi.org/10.1161/01.hyp.0000146536.68208.84

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