Key result
In open-chest dogs, pertussis toxin superfusion blocked coronary microvessel dilation during severe stenosis (-3.9% vs 21.1% in vehicle; P<0.05), indicating G protein involvement in microvascular control.
Population
42 open-chest dogs
Comparison
Pertussis toxin 300 ng/mL superfused onto the… vs Vehicle superfusion
Design
Preclinical
Authors
Loading...
PTX-sensitive G proteins may regulate canine coronary microvascular tone; leaves open any role in human autoregulation or ischemia.
Absolute Event Rate: -3.9% vs 21.1%
p-value: p=< .05
Pertussis toxin-sensitive G proteins are crucially involved in mediating coronary microvascular dilation during autoregulation and ischemia in the canine heart.
Komaru et al. (1994) studied Coronary microvascular tone regulation during autoregulation and ischemia (n=42). Pertussis toxin (PTX) superfusion vs. Vehicle was evaluated on Microvessel diameter change during severe stenosis (p=< .05). In open-chest dogs, pertussis toxin superfusion blocked coronary microvessel dilation during severe stenosis (-3.9% vs 21.1% in vehicle; P<0.05), indicating G protein involvement in microvascular control.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: