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August 1, 1995Cardiovascular Research

Acute and chronic effects of transient myocardial ischemia on sympathetic nerve activity, density, and norepinephrine content

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Key result

Transient myocardial ischemia in dogs acutely increased regional MIBG washout (14.2% vs 5.9%, P<0.01) and reduced tissue norepinephrine, with chronic denervation occurring in some cases.

Why the study?

Does transient myocardial ischemia cause acute and chronic damage to myocardial sympathetic nerves in a dog model?

Population

20 dogs (n=9 for acute studies, n=11 for chronic studies)

Comparison

Transient myocardial ischemia via coronary… vs Non-ischemic control regions within the same…

Design

Preclinical

Follow-up

11 days (for chronic studies)

Authors

MDMichael W. DaeJOJ. William O’ConnellEBElias H. Botvinick

Discussion

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Member takes

Overview

Supports ischemia-induced sympathetic denervation; extends preclinical validation of MIBG for ischemic injury assessment.

Structured PICO

Does transient myocardial ischemia cause acute and chronic damage to myocardial sympathetic nerves in a dog model?

P
Population
20 dogs subjected to acute or chronic transient myocardial ischemia to assess sympathetic nerve function and morphology.
I
Intervention
Transient myocardial ischemia via coronary occlusion (acute) or transient intracoronary balloon occlusion (chronic)
C
Comparator
Non-ischemic control regions within the same subjects
O
Outcome
Sympathetic nerve function and morphology (assessed by I-123 MIBG washout, tissue norepinephrine, and nerve density)surrogate

Main Result

Absolute Event Rate: 14.2% vs 5.9%

p-value: p=<0.01

Transient myocardial ischemia acutely impairs sympathetic nerve function and can lead to chronic denervation even in the absence of transmural myocardial necrosis.

Limitations

  • The mechanisms leading to chronic denervation of sympathetic nerves in the absence of transmural infarction remain to be defined.

Cite This Study

Dae et al. (1995) studied transient myocardial ischemia (n=20). transient myocardial ischemia vs. control region / non-ischemic territory was evaluated on regional MIBG washout during coronary occlusion (p=<0.01). Transient myocardial ischemia in dogs acutely increased regional MIBG washout (14.2% vs 5.9%, P<0.01) and reduced tissue norepinephrine, with chronic denervation occurring in some cases.

synapsesocial.com/papers/6a5db0593ce08021578a9bfahttps://doi.org/10.1016/s0008-6363(95)00039-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduction of sympathetic inotropic response after ischemia in dogs. Contributor to stunned myocardium.1985 · 83 citations
  2. 2Response of post-ischemic myocardium to sympathetic stimulation: Relation to local norepinephrine release.1993 · 2 citations
  3. 3Brief Episode of Myocardial Ischemia Before Prolonged Ischemia Attenuates Cardiac Sympathetic Nerve Injury2006 · 3 citations
  4. 4Scintigraphic and electrophysiological evidence of canine myocardial sympathetic denervation and reinnervation produced by myocardial infarction or phenol application.1988 · 171 citations
  5. 5Ventricular wall motion and NE release in post-ischemic reperfused myocardium.1991