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October 1, 1988CirculationOpen Access

Scintigraphic and electrophysiological evidence of canine myocardial sympathetic denervation and reinnervation produced by myocardial infarction or phenol application.

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Why the study?

Does 123I-labeled MIBG scintigraphy accurately detect regional myocardial sympathetic denervation and reinnervation compared to electrophysiological testing in dogs?

Population

Dogs with epicardial phenol application or transmural myocardial infarction

Comparison

123I-labeled metaiodobenzylguanidine… vs Electrophysiological testing

Design

Preclinical

Follow-up

14 weeks (mean)

Authors

JMJoseph D. MinardoThrombosis Research InstituteMTMahmoud TuliKing Fahad Specialist HospitalBMBruce H. MockIndiana University School of Medicine

Discussion

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Overview

MIBG may track sympathetic reinnervation timing in canine models; leaves open translation to human post-MI imaging.

Structured PICO

Does 123I-labeled MIBG scintigraphy accurately detect regional myocardial sympathetic denervation and reinnervation compared to electrophysiological testing in dogs?

P
Population
Dogs with epicardial phenol application or transmural myocardial infarction
I
Intervention
123I-labeled metaiodobenzylguanidine (MIBG) scintigraphic imaging
C
Comparator
Electrophysiological testing (ansae subclaviae and norepinephrine stimulation)
O
Outcome
Correlation of MIBG scintigraphy with electrophysiological responses to establish the presence of neural denervation and reinnervationsurrogate

MIBG scintigraphy can noninvasively determine the presence of regional myocardial efferent sympathetic denervation and subsequent reinnervation following myocardial infarction or phenol application.

Cite This Study

Minardo et al. (1988) studied this question.

synapsesocial.com/papers/6a70c690f44fa9f079de7946https://doi.org/10.1161/01.cir.78.4.1008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute and chronic effects of transient myocardial ischemia on sympathetic nerve activity, density, and norepinephrine content1995 · 70 citations
  2. 2Metaiodobenzylguanidine [131I] scintigraphy detects impaired myocardial sympathetic neuronal transport function of canine mechanical-overload heart failure.1987 · 43 citations
  3. 3Normal 123I‐MIBG uptake areas may be associated with hyperinnervation and arrhythmia risk in phenol model rabbit hearts2017 · 5 citations
  4. 4Abnormalities of cardiac sympathetic function in pacing-induced heart failure as assessed by [123I]metaiodobenzylguanidine scintigraphy.1994 · 63 citations
  5. 5Presence of sympathetically denervated but viable myocardium and its electrophysiologic correlates after early revascularised, acute myocardial infarction2004 · 128 citations