Key result
Percutaneous closure in patients with very large atrial septal defects (≥35 mm) achieved a 100% procedural success rate, comparable to the 99.1% success rate in patients with large defects (25-34 mm).
Why the study?
The study aimed to compare procedural, early, and long-term outcomes of device closure of atrial septal defect between patients with large ASD and those with very large ASD.
Does percutaneous closure of very large ASDs have similar procedural and long-term outcomes compared to large ASDs in adult patients?
Population
269 adult patients with large ASD (≥25 mm) at a single tertiary center
Comparison
Very large ASD (≥35 mm) vs large ASD (25 mm ≤ ASD < 35 mm)
Design
Single-center retrospective study
Follow-up
47.2±32.0 months (range, 6.0-135.5)
Authors
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Supports percutaneous closure feasibility for very large ASDs; leaves open need for randomized trials to guide practice.
Cohort (n=269)
No
Does percutaneous closure of very large ASDs have similar procedural and long-term outcomes compared to large ASDs in adult patients?
Absolute Event Rate: 100% vs 99.1%
p-value: p=0.620
Percutaneous closure of very large ASDs (≥35 mm) is safe and effective, with procedural and long-term outcomes comparable to those of large ASDs (25-35 mm), despite requiring more modified implantation techniques.
Jung et al. (2019) conducted a cohort in Atrial septal defect (n=269). Very large atrial septal defect (≥35 mm) vs. Large atrial septal defect (25-34 mm) was evaluated on Procedural success rate (p=0.620). Percutaneous closure in patients with very large atrial septal defects (≥35 mm) achieved a 100% procedural success rate, comparable to the 99.1% success rate in patients with large defects (25-34 mm).
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