Key result
Metabolic syndrome was associated with significantly lower hyperemic shear stress (72.0 vs 80.9 dyne/cm2; p<0.001) but not impaired flow-mediated dilatation (p=0.2) in male firefighters.
Why the study?
Is metabolic syndrome associated with impaired vascular function as assessed by FMD and HSS in men without established diabetes and CVD?
Population
1,417 male firefighters without established diabetes and cardiovascular disease
Comparison
Presence of Metabolic Syndrome classified… vs Absence of Metabolic Syndrome
Design
Cross-sectional
Authors
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Hypothesis-generating for selective microvascular impairment in metabolic syndrome; prospective studies needed before clinical adoption.
Cross-Sectional (n=1,417)
Is metabolic syndrome associated with impaired vascular function as assessed by FMD and HSS in men without established diabetes and CVD?
Absolute Event Rate: 72% vs 80.9%
p-value: p=<0.001
Metabolic syndrome is associated with impaired microvascular function (lower hyperemic shear stress) but not impaired flow-mediated dilatation in men without established CVD or diabetes.
Title et al. (2008) conducted a cross-sectional in Metabolic syndrome (n=1,417). Metabolic syndrome vs. Without metabolic syndrome was evaluated on Hyperemic shear stress (HSS) (p=<0.001). Metabolic syndrome was associated with significantly lower hyperemic shear stress (72.0 vs 80.9 dyne/cm2; p<0.001) but not impaired flow-mediated dilatation (p=0.2) in male firefighters.
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