Key result
Among the tested tyrosine kinase inhibitors, only sorafenib directly impaired mitochondrial function at clinically relevant concentrations in isolated rat heart mitochondria and H9c2 cells.
Why the study?
Do tyrosine kinase inhibitors (imatinib, dasatinib, sunitinib, sorafenib) impair mitochondrial function in isolated rat heart mitochondria and H9c2 cells?
Population
Isolated rat heart mitochondria and H9c2 cells
Design
Preclinical
Authors
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May warrant sorafenib-specific cardiac surveillance; leaves open translation of mitochondrial findings to clinical practice.
Do tyrosine kinase inhibitors (imatinib, dasatinib, sunitinib, sorafenib) impair mitochondrial function in isolated rat heart mitochondria and H9c2 cells?
Sorafenib, unlike imatinib, dasatinib, or sunitinib, directly impairs mitochondrial function at clinically relevant concentrations, providing a potential mechanism for its cardiotoxicity.
Will et al. (2008) studied Cardiotoxicity. Tyrosine kinase inhibitors (imatinib, dasatinib, sunitinib, sorafenib) was evaluated on Mitochondrial function (ATP content and respiratory capacity). Among the tested tyrosine kinase inhibitors, only sorafenib directly impaired mitochondrial function at clinically relevant concentrations in isolated rat heart mitochondria and H9c2 cells.
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