Population
Mice and primary cardiomyocyte culture
Design
Preclinical
Follow-up
2 weeks
Authors
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May aid preclinical cardiotoxicity screening of kinase inhibitors; hypothesis-generating for clinical risk prediction and requires validation.
Preclinical kinome and transcriptome profiling reveals broad molecular effects of kinase inhibitors and suggests that combining STAT and EGFR inhibition may cause cardiotoxicity.
Stuhlmiller et al. (2017) studied this question.
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