Key result
In WKY rats, recovery of platelet function after ticagrelor differed mechanistically from clopidogrel, as juvenile platelets formed after clopidogrel treatment promoted thrombus formation.
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Juvenile platelet effects after clopidogrel may differ from ticagrelor in rats; leaves open whether flow-based assays inform human recovery or drug choice.
Megens et al. (2011) studied Platelet function recovery and thrombus formation. Clopidogrel vs. Ticagrelor (40 mg/kg single dose) was evaluated on Thrombus formation under high shear flow conditions. In WKY rats, recovery of platelet function after ticagrelor differed mechanistically from clopidogrel, as juvenile platelets formed after clopidogrel treatment promoted thrombus formation.
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