Why the study?
Does the type of P2Y12 inhibitor taken by patients affect the function of transfused donor platelets?
Population
Blood and plasma from patients treated with clopidogrel, prasugrel, or ticagrelor, and blood from healthy…
Comparison
Patient blood and plasma containing ticagrelor… vs Comparison among the three P2Y12 inhibitors
Design
Preclinical
Authors
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Caution against relying on platelet transfusion for ticagrelor reversal; animal data leave open clinical translation and need for trials.
Does the type of P2Y12 inhibitor taken by patients affect the function of transfused donor platelets?
Ticagrelor, unlike clopidogrel or prasugrel, completely inhibits the function of transfused donor platelets in vitro, suggesting that standard platelet transfusions may be ineffective for reversing ticagrelor-induced bleeding.
Scharbert et al. (2015) studied this question.
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