Key result
The Penn State/3M Health Care electric total artificial heart demonstrated in vivo hemodynamic responses to preload and afterload changes that were similar to those observed in vitro.
Why the study?
Does the Penn State/3M Health Care electric total artificial heart demonstrate similar dynamic performance in vivo compared to in vitro?
Population
Animal model (species not specified in abstract)
Comparison
Penn State/3M Health Care electric total… vs Existing in vitro data
Design
Preclinical
Authors
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May support in vitro model reliability for total artificial hearts; leaves open need for prospective clinical trials.
Does the Penn State/3M Health Care electric total artificial heart demonstrate similar dynamic performance in vivo compared to in vitro?
The Penn State/3M Health Care electric total artificial heart demonstrates expected and appropriate hemodynamic responses to preload and afterload changes in an in vivo animal model, matching in vitro data.
Rosenberg et al. (1998) studied this question. Penn State/3M Health Care electric total artificial heart vs. in vitro data was evaluated on Dynamic in vivo performance (hemodynamic responses to preload and afterload changes). The Penn State/3M Health Care electric total artificial heart demonstrated in vivo hemodynamic responses to preload and afterload changes that were similar to those observed in vitro.
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