What question did this study set out to answer?

Characterize the steady-state hemodynamics, energetic efficiency, and device-tissue thermal interface of a completely implantable total artificial heart designed as a bridge or alternative to cardiac transplantation.

May 1, 1999ASAIO Journal

Steady State Hemodynamic and Energetic Characterization of the Penn State/3M Health Care Total Artificial Heart

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Population

In vitro mock circulatory loop and in vivo acute studies (n=2)

Design

Preclinical

Follow-up

acute

Authors

JWJason WeissUniversity of North Texas GRGerson RosenbergPennsylvania State University ASAlan J. SnyderUnited States Army Medical Command

Discussion

Member takes

Implication

Supports continued TAH preclinical development; leaves open translation to chronic human use.

Key Points

Characterize the steady-state hemodynamics, energetic efficiency, and device-tissue thermal interface of a completely implantable total artificial heart designed as a bridge or alternative to cardiac transplantation.
In vitro testing on a mock circulatory loop utilizing a glycerol/water blood analog at body temperature to measure preload sensitivity, afterload response, and left atrial pressure across varying flow rates.
In vivo evaluation in two acute animal studies measuring thermal transfer to adjacent tissues via temperature sensors placed on the electronics, motor, and transcutaneous energy transmission coil.
In vitro testing demonstrated safe left atrial pressure maintenance below 15 mm Hg across flow outputs up to 7.5 L/min, with robust preload sensitivity largely unaffected by variations in aortic pressure or pulmonary vascular resistance.
In vivo testing showed that the completely implanted system maintained a mean device-tissue interface temperature rise of less than 4 °C above core body temperature.

Structured PICO

Population

In vitro mock circulatory loop and in vivo acute studies (n=2)

Intervention

Penn State/3M Health Care Total Artificial Heart (TAH)

Outcome

Hemodynamic response (preload and afterload response, left atrial pressure control) and energetic performance (power consumption, device-tissue interface temperature)surrogate

The Penn State/3M Health Care Total Artificial Heart demonstrated favorable hemodynamic responses and safe thermal profiles in preclinical in vitro and acute in vivo testing.

Cite This Study

Weiss et al. (1999) studied this question.

synapsesocial.com/papers/6a93bf47213a779dfe720e83 https://doi.org/10.1097/00002480-199905000-00016

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Steady State Hemodynamic and Energetic Characterization of the Penn State/3M Health Care Total Artificial Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Steady State Hemodynamic and Energetic Characterization of the Penn State/3M Health Care Total Artificial Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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