Key result
Ischaemic cerebrovascular disease in acute and convalescent phases was associated with higher median percentage CD62P expression and monocyte-platelet complexes compared to controls (P<=0.02).
Why the study?
Are platelet degranulation and monocyte-platelet complex formation increased in the acute and convalescent phases after ischaemic stroke or TIA compared to controls?
Population
149 patients with ischaemic cerebrovascular disease in acute or convalescent phases after ischaemic stroke…
Design
Cohort
Authors
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Hypothesis-generating for platelet activation in cerebrovascular disease; prospective studies needed before clinical adoption.
Case-Control (n=176)
Are platelet degranulation and monocyte-platelet complex formation increased in the acute and convalescent phases after ischaemic stroke or TIA compared to controls?
p-value: p=<=0.02
Platelet and endothelial activation, evidenced by increased CD62P expression and monocyte-platelet complexes, persists in both acute and convalescent phases of ischaemic stroke or TIA despite antithrombotic therapy.
McCabe et al. (2004) conducted a case-control in Ischaemic stroke or transient ischaemic attack (n=176). Ischaemic cerebrovascular disease vs. Controls without CVD was evaluated on Percentage CD62P expression and monocyte-platelet complexes (p=<=0.02). Ischaemic cerebrovascular disease in acute and convalescent phases was associated with higher median percentage CD62P expression and monocyte-platelet complexes compared to controls (P<=0.02).
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