Key result
The beneficial effect of intensive blood pressure control on heart failure events was not significantly modified by baseline renal function, despite an early decline in eGFR.
Why the study?
Does intensive blood pressure control reduce future heart failure events in non-diabetic patients with hypertension and high cardiovascular risk across the spectrum of baseline renal function?
Design
Editorial
Authors
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Intensive BP lowering prevents HF events across kidney function and albuminuria; extends SPRINT benefits to CKD phenotypes.
Does intensive blood pressure control reduce future heart failure events in non-diabetic patients with hypertension and high cardiovascular risk across the spectrum of baseline renal function?
Worsening renal function during intensive blood pressure control does not negate its benefits in preventing heart failure, suggesting antihypertensive therapy should not be discontinued solely due to an initial creatinine rise.
Ito et al. (2020) conducted an editorial in Hypertension and high cardiovascular risk (n=9,000). Intensive blood pressure control vs. Standard treatment (SBP target <140 mmHg) was evaluated on Composite of myocardial infarction, acute coronary syndrome, stroke, acute heart failure, or death from cardiovascular-related causes. The beneficial effect of intensive blood pressure control on heart failure events was not significantly modified by baseline renal function, despite an early decline in eGFR.
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