Key result
Oral quinine sulfate suppresses electrical storm and long-term ventricular arrhythmias in Brugada syndrome.
Why the study?
Does oral quinine sulfate suppress electrical storm in a patient with Brugada syndrome?
Case Report (n=1)
No
Does oral quinine sulfate suppress electrical storm in a patient with Brugada syndrome?
Oral quinine sulfate can serve as an effective bailout therapy for suppressing electrical storm in Brugada syndrome when standard tertiary care is unavailable.
May offer bailout option for Brugada storm when standard care unavailable; leaves open prospective confirmation before wider use.
Electrical storm is a malignant presentation of Brugada syndrome (BrS). Pharmacologic antiarrhythmic therapy is mandatory for this condition, followed by implantation of an implantable cardioverter-defibrillator to prevent sudden cardiac death. We report a case of a BrS patient presenting with electrical storm in a remote area. A referral to tertiary healthcare services was turned down due to the capacity demands of COVID-19 cases. Oral quinine was used as a bailout therapy and successfully maintained the arrhythmia suppression. Our case confirms that quinine is a reliable option to suppress electrical storm in BrS.
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Amir et al. (2021) conducted a case report in Brugada syndrome with electrical storm (n=1). Oral quinine sulfate was evaluated on Suppression of electrical storm and ventricular arrhythmias. Oral quinine sulfate successfully suppressed electrical storm and maintained long-term ventricular arrhythmia suppression without QTc prolongation in a patient with Brugada syndrome.
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