Muscular work at low oxygen tensions displaced CO2 stimulus-response curves further to the left and increased their steepness compared to the same work intensity in normal air.
How does muscular work at normal and low oxygen tensions affect the ventilatory response to CO2 in humans?
Muscular work and low oxygen tension both increase the sensitivity of the respiratory center to CO2, shifting the stimulus-response curve to the left and increasing its steepness.
Summary. The sensitivity of the respiratory center to CO 2 during muscular work at normal and at low oxygen tensions has been studied in three human subjects. It was found that the rectilinear part of the stimulus‐response curves in normal air was displaced to the left of the resting curve and the more so the higher the work intensity. The steepness of the curves was in the majority of cases about the same. In low oxygen the stimulus‐response curves were displaced more to the left and were much steeper than for the same work intensity in normal air. The flattening of the stimulus‐response curves found at higher CO 2 concentrations is assumed to be due mainly to a special depressant effect of high CO 2 tensions on the respiratory center.
Asmussen et al. (Tue,) reported a other. Muscular work at low oxygen tensions vs. Muscular work at normal oxygen tensions and resting state was evaluated on Sensitivity of the respiratory center to CO2 (stimulus-response curves). Muscular work at low oxygen tensions displaced CO2 stimulus-response curves further to the left and increased their steepness compared to the same work intensity in normal air.