Key result
Steroid therapy in Kawasaki disease was associated with a 64.7% incidence of coronary aneurysms, compared to 20% with antibiotics alone and 11% with aspirin.
Why the study?
Does the type of drug therapy affect the incidence of coronary aneurysms in patients with Kawasaki disease?
Cohort (n=92)
Does the type of drug therapy affect the incidence of coronary aneurysms in patients with Kawasaki disease?
Absolute Event Rate: 64.7% vs 20%
In patients with Kawasaki disease, steroid therapy is associated with a markedly higher incidence of coronary aneurysms compared to aspirin or antibiotics, suggesting an adverse effect on coronary lesions.
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Steroid therapy was associated with higher aneurysm rates in Kawasaki disease; leaves open optimal regimen pending randomized trials.
Kato et al. (1979) conducted a cohort in Kawasaki disease (n=92). Steroid therapy (prednisolone) vs. Antibiotic alone was evaluated on Coronary aneurysms demonstrated by coronary angiography. Steroid therapy in Kawasaki disease was associated with a 64.7% incidence of coronary aneurysms, compared to 20% with antibiotics alone and 11% with aspirin.
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