Key result
Obesity in children was associated with significantly higher hs-CRP levels (4.19 vs 2.2 mg/L, p=0.001) and altered lipid profiles compared to normal-weight controls, with hs-CRP positively correlating with BMI.
Why the study?
Childhood obesity has reached epidemic levels, and hs-CRP is a marker of inflammation and cardiovascular risk with reported links to obesity.
Does obesity in Egyptian children correlate with elevated hs-CRP and altered lipid metabolism?
Case-Control (n=100)
No
Does obesity in Egyptian children correlate with elevated hs-CRP and altered lipid metabolism?
Absolute Event Rate: 4.19% vs 2.2%
p-value: p=0.001
Elevated CRP correlates with BMI and total cholesterol in obese Egyptian children, suggesting a role in predicting altered lipid metabolism and future cardiovascular risk.
hs-CRP elevation in obese children may flag metabolic and CV risk; leaves open whether it predicts events or warrants intervention.
Background Obesity is the most common chronic metabolic disease in children. The global prevalence of obesity has doubled from 1990 to 2015. Worryingly, the increase is more in children than adults. It has reached epidemic ranges and is a significant global problem. High-sensitivity C-reactive protein (hs-CRP) is a parameter that is used to assess inflammation and risk factor for cardiovascular events. Some reports describe an association between hs-CRP and obesity. The objective of the study is to evaluate anthropometric and metabolic parameters in obese Egyptian children and correlate them with hs-CRP level. Results For anthropometric variables, they were significantly higher in obese group than normal weight except for height ( P value 0.001). A significant difference was reported for all lipid profile parameters between obese and normal-weight groups ( P value 0.001). Also, CRP showed a positive correlation with both BMI as well as total cholesterol, while no correlation was observed with other parameters of obesity ( r : 0.41, 0.29 respectively). Conclusion Elevated CRP may have a role in predicting altered lipid metabolism in obese children and this raises the possibility of cardiovascular diseases. Hence, preventive measures to control obesity is necessary.
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Mohamed et al. (2020) conducted a case-control in Childhood obesity (n=100). Obesity vs. Normal weight was evaluated on High-sensitivity C-reactive protein (hs-CRP) level (mg/L) (p=0.001). Obesity in children was associated with significantly higher hs-CRP levels (4.19 vs 2.2 mg/L, p=0.001) and altered lipid profiles compared to normal-weight controls, with hs-CRP positively correlating with BMI.
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