Key result
Overweight and obese adolescents had significantly higher levels of C-reactive protein (P=0.000), neutrophils (P=0.015), and neutrophil/lymphocyte ratio (P=0.034) compared to healthy peers.
Why the study?
Obesity causes inflammation linked to comorbidities such as hypertension and insulin resistance, but the underlying inflammatory events remain obscure, especially in the pediatric age group.
Does overweight and obesity in adolescents associate with an elevated inflammatory state compared to healthy peers?
Case-Control (n=89)
Does overweight and obesity in adolescents associate with an elevated inflammatory state compared to healthy peers?
p-value: P=0.000, P=0.015, P=0.034
Overweight and obese adolescents exhibit a low-grade inflammatory state characterized by elevated CRP, neutrophils, and neutrophil-to-lymphocyte ratio, highlighting early cardiovascular risk.
Elevated CRP and neutrophil ratios signal early inflammation in obese adolescents; hypothesis-generating for future cardiovascular risk.
Background Obesity causes an inflammation state that is related to co-morbidities such as hypertension and insulin resistance. Though, the underlying inflammatory events in obesity are still obscure particularly in pediatric age group. Objective To identify the initial stage of inflammation linked to this nutritional disorder. Materials and methods A case control observational study involved 45 cases of overweight/obese adolescents and 44 healthy peers of matching age and sex. Serum levels of Interleukin-10, Interleukin-18, and C − reactive protein were estimated. Leukocytes, Neutrophils, Lymphocytes counts were determined, and Neutrophil/ Lymphocyte Ratio was calculated. Results and conclusion C − reactive protein, Neutrophils, and Neutrophil/Lymphocyte Ratio were significantly higher in overweight/ obese adolescents ( P = 0.000, P = 0.015, and P = 0.034, respectively). Interleukin-10 was non-significantly lower whereas IL-18 was non-significantly higher in overweight/ obese adolescents ( P = 0.334, and P = 0.427, respectively). Obesity is accompanied by a low inflammatory state that exists since childhood. Therefore, timely interventions should be adopted to preclude the deleterious consequences in grown up adults.
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El-Shaheed et al. (2023) conducted a case-control in Obesity (n=89). Overweight/obesity vs. Healthy peers was evaluated on Inflammatory markers (C-reactive protein, Neutrophils, Neutrophil/Lymphocyte Ratio) (p=P=0.000, P=0.015, P=0.034). Overweight and obese adolescents had significantly higher levels of C-reactive protein (P=0.000), neutrophils (P=0.015), and neutrophil/lymphocyte ratio (P=0.034) compared to healthy peers.
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