Key result
Platelet adhesion increased markedly with increasing hematocrit and peaked within vortices and downstream of reattachment points, corresponding to stagnation points in disturbed flow regions.
Population
In vitro models and isolated transparent natural blood vessels prepared from dogs and humans postmortem.
Design
Preclinical
Authors
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Supports mechanistic studies of hematocrit in disturbed flow; leaves open clinical relevance for thrombosis prevention.
This study demonstrates that local hemodynamics, specifically stagnation points and recirculation zones, play a critical role in platelet adhesion and the localization of thrombosis and atherosclerosis.
Karino et al. (1984) studied Thrombogenesis and atherogenesis. Blood flow patterns and hematocrit variations was evaluated on Platelet adhesion density and flow visualization. Platelet adhesion increased markedly with increasing hematocrit and peaked within vortices and downstream of reattachment points, corresponding to stagnation points in disturbed flow regions.
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