Key result
Higher ideal cardiovascular health metrics were associated with a significantly lower risk of NAFLD, with the highest quartile having an OR of 0.17 (95% CI 0.17-0.20; P<0.001) versus the lowest.
Why the study?
Components of ideal cardiovascular health metrics are associated with NAFLD, but the overall association between ideal CVH metrics and NAFLD required determination.
Does a higher number of ideal cardiovascular health metrics reduce the prevalence of non-alcoholic fatty liver disease in adults?
Cross-Sectional (n=10,511)
Yes
Does a higher number of ideal cardiovascular health metrics reduce the prevalence of non-alcoholic fatty liver disease in adults?
Odds Ratio: 0.17 (95% CI 0.17–0.2)
Absolute Event Rate: 20.89% vs 64.38%
p-value: p=<0.001
Higher ideal cardiovascular health metrics are significantly associated with a lower prevalence of non-alcoholic fatty liver disease.
Ideal CVH metrics were associated with lower NAFLD prevalence; leaves open causality and needs prospective confirmation.
BACKGROUND AND PURPOSE: The components of ideal cardiovascular health (CVH) metrics have been shown to be associated with non-alcoholic fatty liver disease (NAFLD). The present study aimed to determine the association between ideal CVH metrics and NAFLD. METHODS: A total of 10,511 participants (47.26% men) aged 18 to 92 years were selected from the Jidong and Kailuan communities. Ideal CVH was based on 7 ideal CVH metrics: smoking, body mass index (BMI), physical activity, diet, total cholesterol, blood pressure and fasting blood glucose. NAFLD was determined by abdominal ultrasonography. All participants underwent questionnaire assessments and clinical and laboratory examinations. Logistic regression models were used to analyse the relationship of CVH metrics and the number of ideal CVH metrics with NAFLD. RESULTS: The prevalence rates of NAFLD by CVH summary score quartiles were 64.38% (2,015/3,130), 50.16% (786/1,567), 33.28% (1,194/3,588) and 20.89% (465/2,226). Participants in the highest quartile showed a lower odds ratio (OR) than those in the lowest quartile (fully adjusted OR: 0.17, 95% CI: 0.17-0.20, P < 0.001). Similar results were observed in subjects stratified by sex and age (45 years). The ORs were progressively decreased with an increased number of ideal CVH metrics (all P < 0.001). CONCLUSIONS: NAFLD was significantly associated with both the summary score of CVH metrics and the number of ideal CVH metrics. The combined evaluation of ideal CVH may contribute to the prevention of NAFLD.
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Liu et al. (2019) conducted a cross-sectional in Non-alcoholic fatty liver disease (NAFLD) (n=10,511). Ideal cardiovascular health (CVH) metrics vs. Lowest quartile of CVH summary score was evaluated on Non-alcoholic fatty liver disease (NAFLD) (OR 0.17, 95% CI 0.17-0.20, p=<0.001). Higher ideal cardiovascular health metrics were associated with a significantly lower risk of NAFLD, with the highest quartile having an OR of 0.17 (95% CI 0.17-0.20; P<0.001) versus the lowest.
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