Key result
Having 5-7 ideal cardiovascular behaviors and factors was associated with a lower risk of incident NAFLD compared to having 0-2 factors (OR 0.37; 95% CI 0.33-0.41).
Why the study?
Does a higher number of ideal cardiovascular behaviors and factors reduce the incidence of NAFLD?
Cohort (n=25,278)
Does a higher number of ideal cardiovascular behaviors and factors reduce the incidence of NAFLD?
Odds Ratio: 0.37 (95% CI 0.33–0.41)
A higher number of ideal cardiovascular health behaviors and factors is associated with a progressively lower risk of developing nonalcoholic fatty liver disease.
Ideal CVH metrics were associated with lower NAFLD incidence; hypothesis-generating for prevention but requires randomized confirmation.
OBJECTIVE: This study aimed to investigate the association of ideal cardiovascular behaviors and factors with the incidence of nonalcoholic fatty liver disease (NAFLD) prospectively. PATIENTS AND METHODS: We analyzed 25 278 (21 433 men and 11 895 women) participants in the study. Participants were divided into four categories according to the number of ideal cardiovascular behaviors and factors: 0-2, 3, 4, and 5-7 groups. Multivariate logistic regression was used to calculate the odds ratios with 95% confidence intervals (CIs). RESULTS: After adjustment for confounding factors, the multivariate logistic regression model showed that the risk of NAFLD among the groups with 3, 4, 5-7 ideal factors was lower than the 0-2 group; after adjustment for age, sex, income, education level, and other confounders, the odds ratios were 0.74 (95% CI: 0.68-0.80), 0.49 (95% CI: 0.45-0.53), and 0.37 (95% CI: 0.33-0.41), respectively. CONCLUSION: The incidence of NAFLD decreased gradually with increasing ideal cardiovascular health behaviors and factors.
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Zhu et al. (2018) conducted a cohort in Nonalcoholic fatty liver disease (NAFLD) (n=25,278). 5-7 ideal cardiovascular behaviors and factors vs. 0-2 ideal cardiovascular behaviors and factors was evaluated on Incidence of nonalcoholic fatty liver disease (NAFLD) (OR 0.37, 95% CI 0.33-0.41). Having 5-7 ideal cardiovascular behaviors and factors was associated with a lower risk of incident NAFLD compared to having 0-2 factors (OR 0.37; 95% CI 0.33-0.41).
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