Key result
HFrEF shows similar overall trabecular bone scores to controls but poorer quality despite normal BMD.
Why the study?
Data linking bone and heart diseases were limited, with gaps specifically in trabecular bone score analysis.
Population
85 patients with HFrEF and 142 sex-, BMI- and age-matched controls
Comparison
Patients with HFrEF vs sex-, BMI- and age-matched controls
Design
Cross-sectional study
Authors
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May support TBS/VFA use for fracture risk stratification in HFrEF; hypothesis-generating and requires prospective validation.
Cross-Sectional (n=227)
No
Absolute Event Rate: 1.296% vs 1.32%
p-value: p=0.07
Patients with HFrEF exhibit poor bone quality and a high prevalence of fractures, suggesting that TBS and VFA adjustments can improve fracture risk stratification in this population.
Canteri et al. (2023) conducted a cross-sectional in Heart failure with reduced ejection fraction (HFrEF) (n=227). Heart failure with reduced ejection fraction (HFrEF) vs. Sex-, BMI- and age-matched controls was evaluated on Trabecular bone score (TBS) (p=0.07). Patients with HFrEF had similar overall trabecular bone scores compared to matched controls (1.296 vs 1.320, P=0.07), but exhibited significantly poorer bone quality when bone mineral density was normal (P=0.04).
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