A new variant of echovirus 11 caused severe neonatal sepsis and liver failure, with fatal neonatal enterovirus infections increasing to 1.6% in 2022-2023 compared to 0.4% in 2016-2021.
Observational (n=9)
A new variant of echovirus 11 is circulating in France, causing severe and fatal neonatal infections characterized by sepsis and liver failure, warranting national and international alerts.
Absolute Event Rate: 1.6% vs 0.4%
We report nine severe neonatal infections caused by a new variant of echovirus 11. All were male, eight were twins. At illness onset, they were 3-5 days-old and had severe sepsis and liver failure. This new variant, detected in France since April 2022, is still circulating and has caused more fatal neonatal enterovirus infections in 2022 and 2023 (8/496; 1.6%, seven associated with echovirus 11) compared with 2016 to 2021 (7/1,774; 0.4%). National and international alerts are warranted.
Grapin et al. (Thu,) conducted a observational in Severe neonatal infections (n=9). New variant of echovirus 11 vs. 2016-2021 period was evaluated on Fatal neonatal enterovirus infections. A new variant of echovirus 11 caused severe neonatal sepsis and liver failure, with fatal neonatal enterovirus infections increasing to 1.6% in 2022-2023 compared to 0.4% in 2016-2021.