Key result
New European lineage 1 Echovirus 11 linked to fatal multiple-organ failure in three neonates.
Case Report (n=3)
No
Echovirus 11 lineage 1, previously seen in Europe, has emerged in Japan causing fatal neonatal acute liver failure.
Fatal E11 lineage 1 cases in Japanese neonates warrant vigilance; extends European reports to Asia but leaves open prevention and control needs.
In 2022-23, several European countries reported paediatric acute liver failure (ALF) with enterovirus infection. In August-November 2024, three neonatal cases of ALF with echovirus 11 (E11) were reported in Tokyo, Japan. All neonates developed irreversible multiple-organ failure and died. The E11 strain belonged to the new lineage 1, which was the same as strains isolated from neonatal ALF cases in Europe in 2022-23.
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Ikuse et al. (2025) conducted a case report in Neonatal acute liver failure (n=3). Echovirus 11 infection was evaluated on Irreversible multiple-organ failure and death. Echovirus 11 infection in three neonates caused irreversible multiple-organ failure and death, with the strain matching the new lineage 1 isolated in Europe in 2022-23.
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