Case report reveals fatal recurrent hepatitis from echovirus 11 lineage 1 in an immunocompromised adult, highlighting the need to test for this pathogen in unexplained liver disease.
The 2022–2023 European outbreak of severe neonatal hepatitis caused by echovirus 11 (E11) lineage 1 highlighted its pathogenic potential. We describe a fatal, recurrent hepatitis in an immunocompromised adult after B-cell depletion. Sequencing showed E11 lineage 1 infection. E11 lineage 1 should be considered in immunocompromised adults with unexplained hepatitis.
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Harryvan et al. (2026) studied this question.
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