Key result
Enterovirus infection was detected by PCR in 25.8% of febrile infants aged ≤90 days compared to 6.9% of afebrile control infants.
Why the study?
What is the incidence of nonpolio enteroviral infections in febrile versus afebrile infants ≤90 days of age?
Population
431 infants ≤90 days of age, comprising 345 unimmunized febrile infants admitted for sepsis evaluation and…
Comparison
Polymerase chain reaction assay for diagnosis of… vs Afebrile control infants and EV-negative febrile…
Design
Case-control
Authors
Loading...
Supports considering enterovirus in febrile infants ≤90 days; leaves open whether PCR testing improves outcomes.
Case-Control (n=431)
No
What is the incidence of nonpolio enteroviral infections in febrile versus afebrile infants ≤90 days of age?
Absolute Event Rate: 25.8% vs 6.9%
Nonpolio enteroviral infections are a common cause of fever in infants ≤90 days old, and identifying them via PCR may reduce unnecessary antibiotic use and hospital stays.
Byington et al. (1999) conducted a case-control in Febrile illness (n=431). Fever vs. Afebrile was evaluated on Enterovirus positivity by PCR. Enterovirus infection was detected by PCR in 25.8% of febrile infants aged ≤90 days compared to 6.9% of afebrile control infants.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: