Key result
Presence of the syndrome was associated with a significantly higher incidence of (aborted) sudden death compared to unaffected family members (48% vs 6%, P<0.0001).
Observational (n=334)
Absolute Event Rate: 48% vs 6.3%
p-value: p=<0.0001
In families with Brugada syndrome, while the disease is the main cause of sudden death, nearly half of sudden deaths are due to unrelated or unclear causes, highlighting the need for accurate classification.
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Screening Brugada families identifies elevated sudden-death risk; leaves open the proportion due to the channelopathy versus other etiologies.
Josép Brugada (2000) conducted an observational in Syndrome of right bundle branch block, ST segment elevation in leads V1 to V3 and sudden death (n=334). Presence of the syndrome (typical ECG pattern) vs. Unaffected family members was evaluated on (Aborted) sudden death (p=<0.0001). Presence of the syndrome was associated with a significantly higher incidence of (aborted) sudden death compared to unaffected family members (48% vs 6%, P<0.0001).
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