Key result
Paravalvular leak following TAVI in patients with low-gradient severe aortic stenosis was associated with higher 1-year mortality (32% vs 8%, P=0.04) compared to those without leak.
Why the study?
Does paravalvular leak post-TAVI increase mortality in patients with low-gradient severe aortic stenosis?
Population
75 consecutive patients with low-gradient severe aortic stenosis, mean age 80 ± 8 years, 68% male, 89%…
Comparison
Transcatheter aortic valve implantation (TAVI) vs Patients without paravalvular leak (PVL) post-TAVI
Design
Cohort
Follow-up
2 years
Authors
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Aa and BNP may flag PVL risk post-TAVI in LGSAS; leaves open prospective validation before guiding care.
Cohort (n=75)
Does paravalvular leak post-TAVI increase mortality in patients with low-gradient severe aortic stenosis?
Absolute Event Rate: 32% vs 8%
p-value: p=0.04
In patients with low-gradient severe aortic stenosis undergoing TAVI, pre-procedural BNP and aortic cross-sectional area predict paravalvular leak, which is associated with significantly increased 1-year mortality.
Chrysohoou et al. (2014) conducted a cohort in Low-gradient severe aortic stenosis post-TAVI (n=75). Paravalvular leak vs. No paravalvular leak was evaluated on 1-year death rate (p=0.04). Paravalvular leak following TAVI in patients with low-gradient severe aortic stenosis was associated with higher 1-year mortality (32% vs 8%, P=0.04) compared to those without leak.
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