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September 14, 2020Clinical and Experimental Hypertension

Exercise training ameliorates adrenergic control in spontaneously hypertensive rats

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Why the study?

The study was conducted to examine vascular control after sympathetic stimulation by tyramine infusion in hypertensive rats submitted to swimming training.

Does swimming training improve autonomic function and vascular control in spontaneously hypertensive rats?

Population

Male normotensive and hypertensive rats

Comparison

Swimming-trained vs sedentary normotensive and hypertensive rats

Design

Animal experimental study

Key result

Exercise training in spontaneously hypertensive rats significantly attenuated pressor and heart rate responses to tyramine infusion (p < 0.001), improving cardiovascular autonomic dysfunction.

Authors

MMMunique MirandaMLMarina de Paiva LemosJSJeffer Eidi Sasaki

Discussion

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Member takes

Overview

Exercise may improve autonomic balance in hypertension; leaves open translation from rat models to clinical practice.

Structured PICO

Does swimming training improve autonomic function and vascular control in spontaneously hypertensive rats?

P
Population
Male normotensive and spontaneously hypertensive rats assigned to sedentary or swimming training groups.
I
Intervention
Swimming training
C
Comparator
Sedentary control (sedentary normotensive and sedentary hypertensive groups)
O
Outcome
Vascular control after sympathetic stimulation by tyramine infusion (arterial pressure, heart rate, heart rate variability, arterial pressure variability, and cardiac autonomic function)surrogate

Main Result

p-value: p=<0.001

Exercise training attenuates sympathetic nerve ending adjustments and vasoconstrictor effects, improving cardiovascular autonomic dysfunction in a hypertensive rat model.

Cite This Study

Miranda et al. (2020) studied Hypertension. Swimming training vs. Sedentary was evaluated on Pressor and heart rate responses to tyramine infusion (p=<0.001). Exercise training in spontaneously hypertensive rats significantly attenuated pressor and heart rate responses to tyramine infusion (p < 0.001), improving cardiovascular autonomic dysfunction.

synapsesocial.com/papers/6a5ef7d74b5cbccdc3069e6dhttps://doi.org/10.1080/10641963.2020.1817474
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats1997 · 226 citations
  2. 2Exercise Training and Sympathetic Regulation in Experimental Heart Failure2004 · 67 citations
  3. 3Tyramine‐induced endogenous noradrenaline efflux from in situ cardiac sympathetic nerve ending in cats2000 · 14 citations
  4. 4Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles2006 · 89 citations
  5. 5A neural set point for the long-term control of arterial pressure: beyond the arterial baroreceptor reflex2005 · 101 citations