Key result
Network-based expansion of GWAS data across 1,002 human traits identified 73 pleiotropic gene modules, recovering known disease genes and highlighting targets for drug repurposing.
Why the study?
Interacting proteins tend to have similar functions influencing organismal traits, and interaction networks can expand candidate trait-associated genes from genome-wide association studies.
Population
1,002 human traits
Comparison
Network-based expansion of trait-associated genes
Authors
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May inform cardiovascular drug repurposing via pleiotropic targets; extends GWAS interpretation but remains hypothesis-generating pending validation.
Network-based expansion of GWAS data identifies pleiotropic gene modules that can map targets of approved drugs for repurposing and implicate disease-relevant genes.
Barrio‐Hernandez et al. (2023) studied 1,002 human traits (GWAS data). Network-based expansion of trait-associated genes was evaluated on Identification of pleiotropic gene modules linked to multiple traits. Network-based expansion of GWAS data across 1,002 human traits identified 73 pleiotropic gene modules, recovering known disease genes and highlighting targets for drug repurposing.
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